Patients with LMD can receive chemotherapy in three different ways – by swallowing a pill (oral), through a needle in your vein (IV), or intrathecally (IT) which means directly into the cerebral spinal fluid (CSF).
Intrathecal delivery of chemotherapy can occur via a lumbar puncture, or via a special port called an Ommaya. Similar to a port placed in the chest to access blood and deliver drugs directly to the bloodstream, the Ommaya port is surgically implanted in the skull and allows for access to the CSF to deliver drugs directly to the central nervous system. The patient receives a local injection (shot) of an anesthetic to numb the site where the Ommaya port will be placed, which makes the procedure very tolerable for most patients.
|Treatment Options Delivered Directly to the Brain or Spinal Cord for Leptomeningeal Disease
||Breast Cancer Type
||methotrexate, liopsomal cytarabine, topotecan