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Brain Metastases Research Articles 2022

2022

Trastuzumab Deruxtecan for HER2+ MBC With Brain Mets: DESTINY-Breast01 Trial Subgroup Analysis

Jan 3, 2022

Gene involved in sense of smell could play a role in the spread of breast cancer to the brain

Jan 4, 2022

Metabolic diversity within breast cancer brain-tropic cells determines metastatic fitness

Jan 18, 2022

Tucatinib Added to Trastuzumab and Capecitabine for Pretreated HER2+ Metastatic Breast Cancer ± Brain Metastases

Jan 24, 2022

Targeting Brain Metastases in Breast Cancer

Jan 26, 2022

Mapping molecular subtype specific alterations in breast cancer brain metastases identifies clinically relevant vulnerabilities

Jan 28, 2022

Researchers discover new way to target secondary breast cancer that has spread to the brain

Feb 3, 2022

Pyrotinib Plus Capecitabine for Patients With HER2-Positive Breast Cancer and Brain Metastases

Feb 15, 2022

Preclinical and Clinical Efficacy of Trastuzumab Deruxtecan in Breast Cancer Brain Metastases

Feb 25, 2022

Neratinib and Capecitabine for the Treatment of Leptomeningeal Metastases from HER2-Positive Breast Cancer: A Series in the Setting of a Compassionate Program

March 1, 2022

‘Tremendous Hope’ Surrounds Emerging Therapies for Cancer That has Spread to the Brain

March 2, 2022

More Effective, Less Toxic Treatment Approach for Brain Metastases May Improve Care and Survival

March 5, 2022

Brain Metastases Are Now More Treatable in HER2+ Metastatic Breast Cancer

March 8, 2022

p16INK4A-deficiency predicts response to combined HER2 and CDK4/6 inhibition in HER2+ breast cancer brain metastases

March 9, 2022

Trastuzumab Deruxtecan Continues to Elicit Responses in HER2+ Breast Cancer With Active Brain Metastases

March 15, 2022

Assessing CSF ctDNA to Improve Diagnostic Accuracy and Therapeutic Monitoring in Breast Cancer Leptomeningeal Metastasis

March 22, 2022

Incidence of brain metastases in patients with early HER2-positive breast cancer receiving neoadjuvant chemotherapy with trastuzumab and pertuzumab

March 22, 2022

Central nervous system disease in phase III studies for advanced HER2 positive breast cancer: A review

March 22, 2022

Tucatinib versus placebo added to trastuzumab and capecitabine for patients with pretreated HER2+ metastatic breast cancer with and without brain metastases (HER2CLIMB): final overall survival analysis

April 7, 2022

Incidence and impact of brain metastasis in patients with hereditary BRCA1 or BRCA2 mutated invasive breast cancer

April 9, 2022

Brain radiotherapy, tremelimumab-mediated CTLA-4-directed blockade +/− trastuzumab in patients with breast cancer brain metastases

April 22, 2022

Salvage brachytherapy for multiply recurrent metastatic brain tumors: A matched case analysis

May 6, 2022

Emerging Systemic Treatment Perspectives on Brain Metastases: Moving Toward a Better Outlook for Patients

May 22, 2022

Immune Checkpoint Inhibitors in the Treatment of Breast Cancer Brain Metastases

June 28, 2022

Brain metastases: A Society for Neuro-Oncology (SNO) consensus review on current management and future directions

July 8, 2022

Randomized Phase II Trial of Proton Craniospinal Irradiation Versus Photon Involved-Field Radiotherapy for Patients With Solid Tumor Leptomeningeal Metastasis

Brain Metastases Research Articles 2021

Jan 5, 2021

Breast Cancer Brain Metastases: Clinical Challenges and Recent Advancements

Jan 6, 2021

​​Updated ExteNET Data Raise Questions Over TKI Utility in HER2+ Breast Cancer With Brain Metastases

Jan 7, 2022

Leptomeningeal disease and neurologic death after surgical resection and radiosurgery for brain metastases: A multi-institutional analysis

Jan 7, 2021

A solitary brain metastasis as the only site of recurrence of HR positive, HER2 negative breast cancer: a case report and review of the literature

Jan 12, 2021

Tumor DNA Mutations From Intraparenchymal Brain Metastases Are Detectable in CSF

Feb 2, 2021

Managing Patients With HER2+ Breast Cancer and Brain Metastasis: Slides

Feb 3, 2021

MiR-211 determines brain metastasis specificity through SOX11/NGN2 axis in triple-negative breast cancer

Feb 3, 2021

The Genomic Landscape of Breast Cancer Brain Metastases

March 2, 2021

Nancy Lin, MD, on Breast Cancer With Brain Metastasis

March 3, 2021

Antibody-Drug Conjugates, TKIs Drive Improved Outcomes in HER2+ Breast Cancer

March 4, 2021

New Indications in HER2+ Breast Cancer Spark Discussions on Selection, Safety, and Sequencing

March 6, 2021

Research Moves Full Steam Ahead With Brain Metastases, Leptomeningeal Disease in Breast Cancer

March 8, 2021

Immune cell profiling of the cerebrospinal fluid enables the characterization of the brain metastasis microenvironment

March 10, 2021

Modern Approaches to Brain Cancer Metastases in Breast Cancer

March 19, 2021

Outcomes of changing systemic therapy in patients with relapsed breast cancer and 1 to 3 brain metastases

March 20, 2021

2021 Update on Breast Cancer Brain Metastases: Current Treatment Options and Challenges

March 24, 2021

Immunotherapy Shows Promise for Treating Brain Metastases

April 1, 2021

Fatty acid synthesis is required for breast cancer brain metastasis

May 4, 2021

Pertuzumab Plus High-Dose Trastuzumab in Patients With Progressive Brain Metastases and HER2-Positive Metastatic Breast Cancer: Primary Analysis of a Phase II Study

May 12, 2021

Sacituzumab Govitecan Earns Full Approval for Triple-Negative Breast Cancer

May 20, 2021

Stereotactic Radiosurgery for Brainstem Metastases

May 27, 2021

Tumor Control and Risk of Radiation Necrosis Following Stereotactic Radiosurgery for Brain Metastasis

May 28, 2021

Usefulness of assessment of circulating tumor DNA(ctDNA) of cerebrospinal fluid(CSF) samples for early detection of brain metastasis (BrM) in patients with triple-negative breast cancer (TNBC)

June 2, 2021

Pembrolizumab for patients with leptomeningeal metastasis from solid tumors: efficacy, safety, and cerebrospinal fluid biomarkers

June 8, 2021

Clinicopathologic and Genomic Landscape of Breast Carcinoma Brain Metastases

June 15, 2021
2021 ASCO Updates on Systemic Chemotherapy in Patients With Brain Only MBC: A Retrospective Analysis

July 5, 2021

Breast cancer brain metastasis: insight into molecular mechanisms and therapeutic strategies

July 21, 2021

​​Pyrotinib Treatment in Patients With HER2+ Metastatic Breast Cancer and Brain Metastasis

July 22, 2021

New approach eradicates breast cancer in mice

July 28, 2021

​​Genomic Landscape of Breast Carcinoma Brain Metastases

Aug 1, 2021

Aging and CNS Myeloid Cell Depletion Attenuate Breast Cancer Brain Metastasis

Aug 4, 2021

Examining Recent Advances in the Management of Brain Metastases in HER2-Positive Breast Cancer

Aug 5, 2021

EANO–ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up of patients with brain metastasis from solid tumours

Aug 9, 2021

Detection of Leptomeningeal Disease Using Cell-Free DNA From Cerebrospinal Fluid

Sept 8, 2021

Update from HER2CLIMB in Relapsed Refractory HER2-Positive Breast Cancer

Sept 9, 2021

Rapid Readout: Assessment of Tucatinib vs Placebo in the HER2CLIMB Study of Pretreated Patients with HER2+ Metastatic Breast Cancer

Sept 14, 2021

A common goal to CARE: Cancer Advocates, Researchers, and Clinicians Explore current treatments and clinical trials for breast cancer brain metastases

Sept 23, 2021

Different types of cancers are likely to spread to specific areas of the brain

Oct 13, 2021

MR-guided focused ultrasound enhances delivery of trastuzumab to Her2-positive brain metastases

Oct 28, 2021

Immune Checkpoint Inhibitors in Patients With Brain Metastasis

Oct 28, 2021

Patient-Reported Outcomes After a Diagnosis of Brain Metastasis

Nov 15, 2021

Novel prognostic classification predicts overall survival of patients receiving salvage whole-brain radiotherapy for recurrent brain metastasis from breast cancer: A recursive partitioning analysis (KROG 16-12)

Nov 19, 2021

Characterization of plasma circulating small extracellular vesicles in patients with metastatic solid tumors and newly diagnosed brain metastasis

Nov 21, 2021

SNO 2021: Ipilimumab + Nivolumab Appears Promising for Leptomeningeal Carcinomatosis

Nov 27, 2021

Advances in the management of breast cancer brain metastases

Nov 27, 2021

Special issue: advances in the multimodality management of brain metastases and ongoing approaches to further improve their treatment

Nov 30, 2021

Pre-Conference Coverage: Miami Brain Symposium 2021 – Controversies in Metastasis Management

Nov 30, 2021

Phase II trial of carboplatin and bevacizumab in patients with breast cancer brain metastases

Dec 2, 2021

SNO 2021: Neratinib Is Promising for Leptomeningeal Metastases of Heavily Pretreated HER2+ Breast Cancer

Dec 8, 2021

Tucatinib Plus Palbociclib/Letrozole Prolongs CNS-PFS in HR+/HER2+ Breast Cancer

Dec 21, 2021

Treatment for Brain Metastases: ASCO-SNO-ASTRO Guideline

Brain Metastases Research Articles 2020

Jan 15, 2020

Scientists breach brain barriers to attack tumors

Feb 3, 2020

Changing Paradigms in the Management of Brain Metastases

Feb 6, 2020

SABCS Showcased Novel Agents in the HER2+ Breast Cancer Armamentarium

Feb 14, 2020

Hippocampal Avoidance During Whole-Brain Radiotherapy Plus Memantine for Patients With Brain Metastases: Phase III Trial NRG Oncology CC001

Feb 14, 2020

Neurocognitive Outcomes for Patients With Brain Metastasis in the Modern Era: Benefit of Treatment With Hippocampal Avoidance Whole-Brain Radiotherapy Plus Memantine

Feb 20, 2020

Current approaches to the management of brain metastases

Feb 20, 2020

Neoadjuvant Radiosurgery Shows Efficacy for Large Brain Metastases

March 2, 2020

Overcoming the Blood–Brain Barrier in the Management of Brain Tumors

March 16, 2020

Emerging Data for Brain Metastases From HER2+ Breast Cancer

April 1, 2020

Clinical outcome of patients with brain metastases from breast cancer – A population based study over 21 years

April 9, 2020

Temozolomide in secondary prevention of HER2-positive breast cancer brain metastases

May 6, 2020

Focused ultrasound opening brain to previously impossible treatments

May 14, 2020

AACR: Clinical Implications of Mutational Data From Brain Metastases

May 17, 2020

Cellular and Molecular Changes of Brain Metastases-Associated Myeloid Cells during Disease Progression and Therapeutic Response

May 18, 2020

Updates in HER2+ Metastatic Breast Cancer: HER2CLIMB

May 24, 2020

Trastuzumab Deruxtecan Shows Efficacy in HER2+ Breast Cancer Brain Mets

May 26, 2020

Identification of risk factors for central nervous system metastasis in patients with breast cancer with neurologic symptoms

May 27, 2020

Response of Brain Metastases From PIK3CA-Mutant Breast Cancer to Alpelisib

May 29, 2020

Dr. Lin on Updated Findings of HER2CLIMB Study in HER2+ Breast Cancer Brain Mets

June 1, 2020

Explore an available treatment option for patients with HER2+ metastatic breast cancer

June 1, 2020

Receptor Discordance in Breast Cancer Brain Metastases: When Knowledge is Power

June 2, 2020

Single-arm, open-label phase 2 trial of pembrolizumab in patients with leptomeningeal carcinomatosis

June 5, 2020

Sequencing Options Expand for Patients With HER2+ MBC and Brain Metastases

June 8, 2020

ASCO 2020: Immune Profiling of Tumor Microenvironment Predicts Overall Survival in Breast Cancer Brain Metastases

June 15, 2020

Rab11b-mediated integrin recycling promotes brain metastatic adaptation and outgrowth

June 30, 2020

HER2CLIMB: Brain Metastases Data

June 30, 2020

Treatment Choice for Patient Relapsing With Brain Metastases

July 4, 2020

Trastuzumab emtansine (T-DM1) in patients with HER2-positive metastatic breast cancer and brain metastases: exploratory final analysis of cohort 1 from KAMILLA, a single-arm phase IIIb clinical trial

July 17, 2020

Cancer cells deploy lipocalin-2 to collect limiting iron in leptomeningeal metastasis

July 17, 2020

Metastatic HER2+ Breast Cancer Treatment Must Move to Personalized Approach

July 23, 2020

Cancer cells in brain and spinal fluid monopolize iron to survive

July 23, 2020

Liquid Biopsy Detects Brain Cancer and Early-Stage Kidney Cancer

July 23, 2020

T-DM1 in Patients With HER2-Positive Breast Cancer and Brain Metastases: KAMILLA Trial

Aug 4, 2020

Central nervous system miliary metastasis in breast cancer: a case series analysis and proposed identification criteria of a rare metastasis subtype

Aug 18, 2020

Cortisol promotes breast-to-brain metastasis through the blood-cerebrospinal fluid barrier

Aug 20, 2020

​​The Brain Microenvironment Induces DNMT1 Suppression and Indolence of Metastatic Cancer Cells

Aug 31, 2020

Targeting HER2 in Breast Cancer Patients With Brain Metastases

Sept 3, 2020

Intra-CSF topotecan in treatment of breast cancer patients with leptomeningeal metastases

Sept 14, 2020

Stereotactic Radiosurgery in Combination With Anti-HER2 Therapy for HER2+ Breast Cancer Brain Metastases

Sept 18, 2020

A risk stratification model for predicting brain metastasis and brain screening benefit in patients with metastatic triple-negative breast cancer

Sept 23, 2020

Novel breast cancer treatment ready for phase 3 trial

Oct 1, 2020

​​​​LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy

Oct 3, 2020

Survival in Patients With Brain Metastases

Oct 9, 2020

Scientists discover key gene driving breast cancer to the brain

Oct 15, 2020

HSRT a Good Option for Resection Cavity of Brain Metastases

Oct 31, 2020

ASTRO 2020: Addition of Immunotherapy to Radiation Improves Survival in Patients With Brain Metastases Initially Treated Surgically

Oct 31, 2020

ASTRO 2020: Cognition is Worsened More by Whole-brain Radiotherapy Than Stereotactic Radiosurgery for Brain Metastases

Oct 31, 2020

ASTRO 2020: Stereotactic Radiosurgery Superior to Whole-Brain Radiotherapy for Patients With Numerous Brain Metastases

Oct 31, 2020

ASTRO 2020: Study Fails to Demonstrate That Timing Between Planning MRI and Stereotactic Radiosurgery Affects Survival of Patients With Brain Metastases

Nov 12, 2020

Pembrolizumab Shows Intriguing Benefit in Leptomeningeal Metastasis From Solid Tumors

Nov 25, 2020

SNO 2020: Bevacizumab + Chemotherapy or Immune Checkpoint Inhibition ± Chemotherapy Can Reduce First or New Brain Metastases by 30%

Nov 25, 2020

SNO 2020: Lapatinib + WBRT/SRS Trends Toward Improvement of Brain Metastases From HER2+ Breast Cancer​​

Dec 9, 2020

HIF1A signaling selectively supports proliferation of breast cancer in the brain

Dec 9, 2020

SABCS 2020: Benefits of Neratinib Over Lapatinib for Breast Cancer Appear Independent of Baseline Central Nervous System Metastases

Dec 16, 2020

2020 Top Stories in Brain Cancer: Hippocampal Avoidance WBRT Plus Memantine in Patients With Brain Metastases

Dec 17, 2020

2020 Top Stories in Metastatic Breast Cancer: Progress in Targeting a Sanctuary Site: Brain Mets in MBC

Dec 23, 2o20

Prognostic validation and clinical implications of the EANO ESMO classification of leptomeningeal metastasis from solid tumors

Brain Metastases Research Articles 2019

Jan 24, 2019

A blazing landscape: Neuroinflammation shapes brain metastasis

Feb 22, 2019

Estradiol induces BDNF/TrkB signaling in triple-negative breast cancer to promote brain metastases

June 4, 2019

Advanced Magnetic Resonance Imaging Techniques in Management of Brain Metastases

July 19, 2019

FABP7 is a key metabolic regulator in HER2+ breast cancer brain metastasis

July 29, 2019

Newer Treatments and Combinations Emerging for Breast Cancer Brain Metastases

Aug 23, 2019

Targeting the Sanctuary Site: Options when Breast Cancer Metastasizes to the Brain

Sept 4, 2019

Current Drug Treatment Approaches for Brain Metastases

Sept 11, 2019

Current Radiation Treatment Approaches for Brain Metastases

Sept 11, 2019

Utilizing Multidisciplinary Immunotherapy Strategies in the Treatment of Solid Tumor Brain Metastases

Sept 27, 2019

​​Breast Cancer Brain Metastases: New Initial Therapy Options

Sept 19, 2019

Cancer Metastasis – Moving From Breast to Brain

Oct 3, 2019

​​Patterns of recurrence and metastasis in BRCA1/BRCA2-associated breast cancers

Oct 14, 2019

High-dose intravenous methotrexate in the management of breast cancer with leptomeningeal disease: Case series and review of the literature

Nov 29, 2019

Response to Olaparib in a Patient with Germline BRCA2 Mutation and Breast Cancer Leptomeningeal Carcinomatosis

Dec 1, 2019

Polyunsaturated Fatty Acids from Astrocytes Activate PPARγ Signaling in Cancer Cells to Promote Brain Metastasis

Dec 6, 2019

Proton Craniospinal Irradiation for Leptomeningeal Disease

Dec 8, 2019

Update on Immunotherapy and Targeted Therapy for Brain Metastases

Brain Metastases Research Articles 2018

June 11, 2018

Examining the survival benefit of radiation therapy on leptomeningeal carcinomatosis and identifying factors associated with survival benefit of whole-brain radiation therapy

Oct 1, 2018

Treatment and outcomes of patients in the Brain Metastases in Breast Cancer Network Registry

Brain Metastases Research Articles 2017

June 26, 2017

Efficacy of Liposomal Cytarabine in the Treatment of Leptomeningeal Metastasis of Breast Cancer

Oct 2, 2017

Modernizing Clinical Trial Eligibility Criteria: Recommendations of the American Society of Clinical Oncology–Friends of Cancer Research Brain Metastases Working Group

Brain Metastases Research Articles 2016

July 25, 2016

Characteristics and outcomes of breast cancer patients with leptomeningeal metastasis